Table 2.
Summary of pharmacokinetic parameters.
| Group 1 | Group 2 | Group 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 330 µg t.d.s. | 500 µg b.d. | 500 µg t.d.s. | 750 µg b.d. | 830 µg t.d.s. | 1250 µg b.d. | ||||||||
| Dofetilide dose measurement | Day 1 | Day 5 | Day 1 | Day 5 | Day 1 | Day 5 | Day 1 | Day 5 | Day 1 | Day 5 | Day 1 | Day 5 | |
| Ctrough (ng ml−1) | Mean | < 0.04 | 1.61 | < 0.04 | 1.24 | < 0.04 | 2.24 | < 0.04 | 2.11 | < 0.04 | 3.65 | < 0.04 | 2.56 |
| s.e.mean | 0.1 | 0.13 | 0.29 | 0.43 | 0.17 | 0.11 | |||||||
| n | 7 | 7 | 7 | 7 | 8 | 8 | 8 | 8 | 7 | 7 | 7 | 7 | |
| Cmax (ng ml−1) | Mean | 1.70 | 3.04 | 2.64 | 3.80 | 2.26 | 4.78 | 3.54 | 5.23 | 3.55 | 7.71 | 5.47 | 10.07 |
| s.e.mean | 0.07 | 0.19 | 0.11 | 0.19 | 0.09 | 0.25 | 0.21 | 0.28 | 0.14 | 0.60 | 0.28 | 0.70 | |
| n | 7 | 7 | 7 | 7 | 8 | 8 | 8 | 8 | 7 | 7 | 7 | 7 | |
| tmax (h) | Mean | 2.29 | 2.29 | 2.00 | 2.00 | 2.13 | 2.00 | 2.13 | 1.88 | 2.29 | 2.14 | 1.57 | 1.57 |
| s.e.mean | 0.18 | 0.18 | 0.31 | 0.22 | 0.13 | 0.00 | 0.13 | 0.40 | 0.18 | 0.14 | 0.20 | 0.30 | |
| n | 7 | 7 | 7 | 7 | 8 | 8 | 8 | 8 | 7 | 7 | 7 | 7 | |
| AUC(0,τ) | Mean | 8.61 | 16.75 | 17.03 | 25.39 | 10.81 | 25.54 | 23.55 | 37.50 | 18.89 | 40.10 | 37.50 | 62.07 |
| (ng ml−1h) | s.e.mean. | 0.43 | 0.86 | 0.82 | 1.48 | 0.34 | 1.74 | 1.32 | 2.62 | 0.75 | 2.05 | 27 | 2.92 |
| n | 7 | 7 | 7 | 7 | 8 | 8 | 8 | 8 | 7 | 7 | 7 | 7 | |
| Kel (h−1) | Mean | 0.700 | 0.068 | 0.073 | 0.069 | 0.073 | 0.069 | ||||||
| s.e.mean | 0.002 | 0.0029 | 0.0024 | 0.0022 | 0.0023 | 0.0026 | |||||||
| n | 7 | 7 | 8 | 8 | 7 | 7 | |||||||