Table 3.
Slope of change in the QTc interval vs mean dofetilide plasma concentration.
| Day | Group | Regimen (µg) | Mean slope from all data points (ms/ng ml−1) | Mean slope (s.d.) based on analysis of each subject (ms/ng ml−1) |
|---|---|---|---|---|
| Day 1 | Group 1 | 330 three times daily | 14.2 | 20.7 (4.5) |
| 500 twice daily | 14.1 | 15.6 (2.4) | ||
| Group 2 | 500 three times daily | 12.9 | 18.7 (4.5) | |
| 750 twice daily | 13.3 | 14.5 (4.1) | ||
| Group 3 | 830 three times daily | 14.1 | 15.1 (3.3) | |
| 1250 twice daily | 17.2 | 16.2 (2.7) | ||
| Day 5 | Group 1 | 330 three times daily | 12.8 | 16.0 (4.1) |
| 500 twice daily | 11.2 | 13.2 (2.3) | ||
| Group 2 | 500 three times daily | 11.1 | 13.0 (2.9) | |
| 750 twice daily | 12.5 | 13.3 (2.2) | ||
| Group 3 | 830 three times daily | 11.1 | 11.2 (1.6) | |
| 1250 twice daily | 9.9 | 11.1 (2.1) |