Table 1.
Pharmacokinetic parameters of lithium.
| Treatment | Comparison | ||
|---|---|---|---|
| LI | LI + LTG | (LI + LTG)/LI | |
| Cmax (mm) | 0.71 (0.08) | 0.65 (0.07) | 0.92 (0.88, 0.97) |
| tmax (h) | 1.75 (0.79) | 1.69 (0.97) | 0.00 (−0.75, 0.75) |
| AUC(0,12h) (mmh) | 6.23 (0.78) | 5.75 (0.73) | 0.92 (0.90, 0.95) |
| Ae(0,12h) (mmol) | 11.2 (1.6) | 9.58 (1.34) | 0.86 (0.79, 0.93) |
| CLR,(l h−1) | 1.83 (0.37) | 1.70 (0.30) | 0.93 (0.85, 1.02) |
LI: lithium. LTG: lamotrigine. For parameters except tmax, values are presented as mean (s.d.) for each treatment and geometric least squares mean ratio (95% confidence interval) for treatment comparison. For tmax, values are presented as mean (s.d.) for each treatment and median difference (95% confidence interval) for treatment comparison. n = 20, except for Ae(0,12h) and CLR during combination treatment, where n = 19 since urine collection by one subject was incomplete.