Table 1.

Mean pharmacokinetic parameters of Z13752A ± s.d.

Z13752A dose	Cmax (µg ml−1)	tmax (h)	AUC (µg ml−1 h)	t½ (h)
10 mg	0.9 ± 0.2	2.2 ± 0.9	8.1 ± 2.6	8.6 ± 5.2
20 mg	2.2 ± 0.7	2.4 ± 0.7	16.9 ± 4.8	8.5 ± 3.8
50 mg	7.4 ± 1.7	1.7 ± 0.7	57.8 ± 9.0	11.2 ± 2.5
100 mg	15.6 ± 3.4	2.0 ± 0.5	137.1 ± 31.8	10.6 ± 1.5
200 mg	26.9 ± 8.2	2.3 ± 0.5	253.3 ± 62.8	11.0 ± 2.3
400 mg	58.1 ± 7.7	2.8 ± 0.8	545.6 ± 85.3	13.0 ± 5.2
600 mg	95.9 ± 20.9	2.7 ± 0.5	889.7 ± 113.6	11.0 ± 1.4
800 mg	107.7 ± 13.3	2.8 ± 0.8	1058.2 ± 194.9	11.0 ± 1.6