Table 2.
Median values and 95% confidence intervals for all significant (S) and non significant (NS) differences between Z13752A doses and placebo.
| Biomarkers of ACE and NEP activity | 10 mg | 20 mg | 50 mg | 100 mg | 200 mg | 400 mg | 600 mg | 800 mg |
|---|---|---|---|---|---|---|---|---|
| Serum ACE (% of predose values h−1) | −10.3 | −17.7 | −33.6 | −54.1 | −59.4 | −78.6 | −71.5 | −84.9 |
| (5.4, −22.3) | (10.2, −41.6) | (−4.3, −52.5) | (−8.5, −87.6) | (32.8, −79.6) | (−64.3, −92.2) | (−64.0, −80.1) | (−72.8, −97.8) | |
| NS | NS | S | S | S | S | S | S | |
| Plasma ANP (% changes of predose values h−1) | 1457 | −122 | 468 | 1165 | 775 | 450 | 2710 | 1838 |
| (−1336, 4249) | (−2792, 2547) | (−2607, 3543) | (−1505, 3835) | (−1834, 3384) | (−2220, 3120) | (231, 5189) | (−831, 4509) | |
| NS | NS | NS | NS | NS | NS | S | NS | |
| Plasma cGMP (% changes of predose values h−1) | 19.2 | 15.3 | 39.8 | 20.3 | 33.5 | 43.9 | 76.7 | 21.6 |
| (−10.1, 48.5) | (−10.4, 41.0) | (10.5, 69.1) | (−4.2, 47.3) | (4.2, 62.8) | (18.2, 69.6) | (47.4, 106.0) | (−4.2, 47.3) | |
| NS | NS | S | NS | S | S | S | NS | |
| 24h urinary cGMP (mmol ml−1) | 52 | 172 | 364 | 367 | 609 | 879 | 466 | 494 |
| (−321, 425) | (−355, 700) | (−9, 738) | (−160, 895) | (237, 983) | (351, 1407) | (93, 840) | (−33, 1022) | |
| NS | NS | NS | NS | S | S | S | NS |