Table 2.

Parameter estimates of population pharmacokinetic models.

Drug	CL (l h−1)	Vd (l)	ωCL	ωVd	σ
Doxorubicin	54.0	9.3	0.0296	0.0369	0.0140
	s.d.: 4.96	s.d.:0.970	s.d.:0.0012	s.d.:0.0020	0.0015 s.d.:0.0085
Etoposide	3.34–0.0083*SCr	6.4	0.0243	0.0350	0.0576
	s.d.:0.228	s.d.:0.863	s.d.:0.0107	s.d.:0.0128	s.d.:0.0213
Ifosfamide	Day 1 : 5.6	26.0	0.0100	0.0296	0.0042
	s.d.:0.330	s.d.:0 4.49	s.d.:0.0044	s.d.:0.0084	0.2100
	Day 2 : 7.95				s.d.:0.0043
	s.d.:0.450

CL: Clearance. V_d: Volume of distribution. S_Cr: Serum creatinine (µmol l⁻¹).