Table 2.
Summary of observed and calculated kinetic parameters values of caffeine (as medians) in control subjects and PD patients1.
| Parameters2 | Control subjects | Untreated PD | Treated PD |
|---|---|---|---|
| CA(0) | 587 [254-964] | 339 [101-756]3 | 162 [41-651]3 |
| CA(2) | 1400 [780-2048] | 1025 [671-1891] | 993 [858-1546]3 |
| CA(2)cor | 1026 [567-1388] | 740 [557-1425] | 706 [506-1116] |
| CA(5) | 849 [430-1298] | 596 [330-953] | 467 [252-869]3 |
| CA(5)cor | 593 [291-841] | 425 [284-858] | 371 [200-650]3 |
| CA t1/2 | 351 [204-446] | 197 [141-324]3 | 223 [129-341]3 |
| PX(0) | 390 [209-643] | 268 [174-442] | 242 [79-451]3 |
| PX(2) | 644 [366-879] | 427 [281-587]3 | 533 [316-743] |
| PX(2)cor | 423 [161-579] | 350 [184-517] | 322 [152-544] |
| PX(5) | 509 [364-686] | 357 [227-518] | 376 [217-579] |
| PX(5)cor | 358 [131-519] | 300 [151-475] | 255 [130-436] |
| PX t1/2 | 585 [185-621] | 479 [3-1345] | 355 [154-835] |
| PX/CA (0) | 0.43 [0.30-0.93] | 0.38 [0.12-0.64]3 | 0.37 [0.12-0.67]3 |
| PX/CA (2)cor | 0.40 [0.20-0.71] | 0.42 [0.21-0.63] | 0.44 [0.22-0.74] |
| PX/CA (5)cor | 0.62 [0.30-0.92] | 0.63 [0.32-1.00] | 0.66 [0.35-1.07] |
1
Numbers in bracket show the time of sampling; numbers in square bracket show the values for first and third quartiles; subscript ‘cor’ shows that the corresponding parameter value is obtained after correction for baseline (see Methods for details).
2
Concentrations values for CA and PX are in ng ml−1; half-life values are in min.
3
Significantly different from control subjects (at α≤0.02).