Table 1.
Characteristics of the cohorts.
| Omeprazole | Lansoprazole | Pantoprazole | |
|---|---|---|---|
| Dates of prescriptions | June 1989 to July 1990 | May to November 1994 | December 1996 to June 1997 |
| Total number of green forms posted | 28 496 | 36 722 | 28,159 |
| Total number of green forms returned (% response rates) | 16 205 (56.9) | 17 329 (47.2) | 11 541 (41.0) |
| Total number of patient-months of exposure† | 58268 | 46248 | 28396 |
| Median (IQR¶) number of patient-months of exposure† | 2.6 (1.0–6.0) | 1.7 (0.9–6.0) | 1.9 (0.9–6.0) |
| Males (%) | 7970 (49.2) | 8160 (47.1) | 5350 (46.4) |
| Females (%) | 8073 (49.8) | 8975 (51.8) | 6068 (52.6) |
| Sex not reported (%) | 162 (1.0) | 194 (1.1) | 123 (1.1) |
| Mean age (years) (s.d.*) | 58.1 (16.4) | 55.4 (16.6) | 55.9 (16.5) |
| Indication‡(%Φ) | |||
| Oesophageal reflux/oesophagitis | 5720 (40.8) | 6727 (45.2) | 3276 (42.1) |
| Ulcer peptic/oesophageal | 2411 (17.2) | 1110 (7.5) | 410 (5.3) |
| Hiatus hernia | 1619 (11.5) | 692 (4.6) | 338 (4.3) |
| Dyspepsia | 1352 (9.6) | 2773 (18.6) | 1951 (25.1) |
| Abdominal pain | 712 (5.1) | 1478 (9.9) | 688 (8.8) |
| Other | 2217 (15.8) | 2105 (14.1) | 1122 (14.4) |
| Total with known indication | 14031 | 14885 | 7785 |
†
In the first 6 months of the study for each patient.
¶
Interquartile range.
*
Standard deviation.
‡
Ranked by frequency of report in omeprazole cohort.
Φ%
of total with known indication.