Table 1a.

Mean pharmacokinetic parameters on day 10 following treatment with loratadine, ketoconazole, or loratadine plus ketoconazole.

Treatment	Analyte	Cmax* (mean,%CV)	tmax (h) (mean,%CV)	AUC(0,24h)† (mean,%CV)
Loratadine	Loratadine	4.64 (75)	1.20 (27)	16.6 (77)
	Desloratadine	6.63 (83)	2.96 (102)	112 (130)
Ketoconazole	Ketoconazole	5.32 (39)	3.80 (151)	53.9 (51)
Loratadine plus ketoconazole	Loratadine	12.6 (45)	1.50 (53)	57.6 (62)
	Desloratadine	11.7 (89)	5.0 (88)	204 (113)
	Ketoconazole	5.11 (42)	2.70 (157)	51.8 (52)

^*ng ml ⁻¹ for loratadine and desloratadine, µg ml⁻¹ for ketoconazole.

^†ng ml ⁻¹ h for loratadine and desloratadine, µg ml⁻¹ h for ketoconazole.