Table 1b.

Mean pharmacokinetic parameters on day 10 following treatment with loratadine, cimetidine, or loratadine plus cimetidine.

Treatment	Analyte	Cmax* (mean,%CV)	tmax (h) (mean,%CV)	AUC(0,24h) † (mean,%CV)
Loratadine	Loratadine	4.73 (119)	1.56 (66)	24.1 (157)
	Desloratadine	5.25 (87)	3.00 (77)	83.0 (117)
Cimetidine	Cimetidine	1.76 (30)	7.83 (45)	19.2 (23)
Loratadine plus cimetidine	Loratadine	8.14 (77)	1.63 (49)	40.9 (135)
	Desloratadine	5.55 (87)	3.31 (80)	88.2 (29)
	Cimetidine	1.64 (39)	7.83 (43)	18.1 (29)

^*ng ml ⁻¹ for loratadine and desloratadine, µg ml⁻¹ for cimetidine.

^†ng ml ⁻¹ h for loratadine and desloratadine, µg ml⁻¹ h for cimetidine.