Table 2.
Linear regression analysis of halofantrine isomer concentration vs electrocardiographic QTc interval.
| Subject | (+)-Halofantrine vs QTc interval | (−)-Halofantrine vs QTc interval | ||||
|---|---|---|---|---|---|---|
| r | 95% CI | P value | r | 95% CI | P value | |
| 01 | 0.361 | 0.132,0.553 | 0.0025 | 0.308 | 0.061,0.520 | 0.0153 |
| 02 | 0.511 | 0.265,0.694 | 0.0002 | 0.447 | 0.183,0.651 | 0.0014 |
| 04 | 0.334 | 0.070,0.554 | 0.0141 | 0.272 | −0.004,0.509 | 0.0532 |
| 05 | 0.021 | −0.262,0.300 | 0.8867 | −0.067 | −0.354,0.231 | 0.6637 |
| 07 | 0.255 | 0.018,0.465 | 0.0355 | 0.120 | −0.124,0.350 | 0.3347 |
| 08 | 0.569 | 0.241,0.780 | 0.0016 | 0.429 | 0.059,0.696 | 0.0246 |
| 09 | 0.238 | 0.003,0.448 | 0.0470 | 0.189 | −0.048,0.406 | 0.1174 |
| 10 | 0.525 | 0.328,0.678 | 0.0000 | 0.487 | 0.281,0.650 | 0.0000 |
| 11 | 0.339 | 0.106,0.537 | 0.0051 | 0.268 | 0.026,0.480 | 0.0305 |
| 14 | 0.522 | 0.293,0.694 | 0.0000 | 0.352 | 0.079,0.576 | 0.0126 |
| 15 | 0.379 | 0.160,0.563 | 0.0010 | 0.472 | 0.260,0.641 | 0.0000 |
| 16 | 0.555 | 0.362,0.703 | 0.0000 | 0.415 | 0.182,0.604 | 0.0008 |
| 18 | 0.455 | 0.241,0.627 | 0.0001 | 0.349 | 0.119,0.544 | 0.0036 |
| 19 | 0.168 | −0.081,0.397 | 0.1853 | 0.131 | −0.119,0.365 | 0.3035 |
| 20 | 0.567 | 0.364,0.719 | 0.0000 | 0.487 | 0.257,0.665 | 0.0001 |