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Effect of specific CYP inhibitors on the rate of N-demethylation of sildenafil (2.5 µm and 250 µm). The values are mean±s.d. of triplicate determinations in microsomes prepared from a pool of four human livers. *P < 0.01; **P < 0.001 compared with the control value. sulph, sulphaphenazole; keto, ketoconazole.
