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Apparent kinetic parameters for the N-demethylation of sildenafil in three human livers.
| High affinity | Low affinity | |||
|---|---|---|---|---|
| Human liver | Km (µm) | Vmax (pmol mg−1 min−1) | Km (µm) | Vmax (pmol mg−1 min−1) |
| HM6 | 3 | 29 | 75 | 224 |
| HM10 | 7 | 11 | 129 | 75 |
| HM13 | 8 | 27 | 39 | 115 |
| Mean ± s.d. | 6 ± 3 | 22 ± 9 | 81 ± 45 | 138 ± 77 |
