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Mean lung deposition (% ex-valve dose) from a pMDI and from a pMDI plus Nebuhaler spacer device. The mean increase in FEV1 produced by 1600 μg daily from pMDI and pMDI plus Nebuhaler are in the same ratio as lung deposition values for the two products. Data from Newman et al. [28] and Toogood et al. [30].
