Table 5.
Effect of haemodialysis on the pharmacokinetics of ziprasidone in subjects with severely impaired renal function.
| Pharmacokinetic parameter | Non-haemodialysis day (Day 7) (n = 9) | Haemodialysis day (Day 8) (n = 9) |
|---|---|---|
| AUC(0,12 h)a (ng ml−1 h) | 334 ± 84a | 427 ± 183a |
| Cmaxa, c (ng ml−1) | 51 ± 10 | 70 ± 29 |
| tmaxb, d (h) | 4 ± 2 | 5 ± 1 |
a
Geometric means and s.d.
b
Arithmetic means and s.d.
c
Statistically significant difference between day 7 and day 8, P =0.0258.
d
Statistical comparison between days not performed.