Table 3.

Serum prolactin concentrations (ng ml⁻¹) (change from baseline).

	Ziprasidone daily dosage
	10 mg day−1	40 mg day−1	40–80 mg day−1	40–120 mg day−1	Placebo
Baseline
Prolactin	10.47	12.14	9.88	9.63	9.91
Number of subjects	6	8	8	7	10
Day 1
Number of subjects	6	8	8	7	10
Ziprasidone dose (mg)	5	20	20	20
Maximum postdose prolactin	21.57	36.14	37.56	30.56	15.9
	(+ 11.10)	(+ 24.00)	(+ 27.68)	(+ 20.93)	(+ 5.28)
12 h postdose prolactin	10.99	12.58	8.29	10.87	10.56
	(+ 0.52)	(+ 0.44)	(−1.59)	(+ 1.24)	(+ 0.65)
Day 18
Number of subjects	6	6	6	6	6
Ziprasidone dose (mg day−1)	10	40	80	120
Maximum postdose prolactin	18.24	22.64	38.75	30.01	15.81
	(+ 7.77)	(+ 10.50)	(+ 28.87)	(+ 20.38)	(+ 5.90)
12 h postdose prolactin	7.04	5.66	6.68	11.55	10.03
	(−3.43)	(−6.48)	(−3.20)	(+ 1.92)	(+ 0.12)

Maximal elevations with ziprasidone reported at 2–6 h postdose. Normal limits for men for the assay used=3–14.7 ng ml⁻¹.