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Summary of urinary dextromethorphan/dextrorphan ratios
| Parameter | Ziprasidone (n = 8) | Paroxetine (n = 7)a | Placebo (n = 8) |
|---|---|---|---|
| Mean baseline value | 0.009 | 0.007 | 0.005 |
| Mean value after treatment | 0.007 | 0.072 | 0.004 |
| Mean± s.d. change | −0.002 ± 0.004 | 0.065 ± 0.043 | −0.001 ± 0.001 |
| P value vs placebo | 0.9231 | 0.0001 | – |
| P value vs paroxetine | 0.0001 | – | – |
Excludes one subject who received paroxetine but in whom the drug was not detectable in plasma during the 10 h postdose sampling period.
