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Schematic representation of the proposed model. Glc, glucose; Glu, glutamate; Gln, glutamine; NH3, ammonia; Vtrans, rate of ammonia transport into the brain; Vefflux, rate of glutamine efflux from the brain; Vpc, anaplerotic flux; Vcycle, rate of neurotransmitter cycling; Vgln, rate of glutamine synthesis.
