Gating properties in G230E hClC-1 channels. (A) Voltage dependence of the time constants of deactivation. Closed circles, τ1; open squares, τ2 (mean ± SEM from four different cells). (B) Voltage dependence of the fractional current amplitudes. Closed circles, A1, open squares, A2, and closed triangles, C. (C) Voltage dependence of activation for G230E (mean ± SEM, n = 6) and WT hClC-1 (WT data are taken from figure 6 of reference 15).