Table 2 Recent trials of calcium channel blockers for chronic stable angina.

Study name	n	Patients studied	Treatment arms	Major findings
A Coronary disease Trial Investigating Outcome with Nifedipine (ACTION)	3825	Symptomatic, stable chronic angina, ambulatory, age 35 years, symptoms present ⩾1 month	GITS 60 mg vs placebo	1. Safe: No ↑MI or CHF
				2. ↓Need for coronary angiography and PCI
Comparison of Amlodipine vs Enalapril to Limit Occurrences of Thrombosis (CAMELOT)	1997	Symptomatic patients requiring angiography for evaluation of chest pain, angiographically documented CAD, diastolic BP <100 mg Hg	Amlodipine 10 mg vs enalapril 20 mg vs placebo	1. ↓Cardiovascular events
				2. ↓Progression of atherosclerosis as assessed by IVUS

BP, blood pressure; CHF, congestive heart failure; GITS, gastrointestinal therapeutic system formulation of nifedipine; IVUS, intravascular ultrasound; MI, myocardial infarction; PCI, percutaneous coronary intervention.