Figure 5.

Inhibitor binding site. Conformational differences between the Y-3- ASV IN (core) complex [pH 5.6 (green)] and the unliganded enzyme, Protein Data Bank code 1ASV (magenta). (A) Residues with altered conformation are labeled. For Arg 158, one of two alternate conformations is shown. The bound Y-3 molecule and its symmetry-related copy are both shown. (B) Conformational changes in the flexible loop sections (residues 141–146) with bound inhibitor molecules.