Table 2.
Residues in positions 1 through 9 of the integrin calcium binding site present in FG-GAP repeat 4 of some and repeats 5, 6, and 7 of all integrins compared with the corresponding residues in EF hand calcium binding sites
| Residue or residue group | Sequence Position
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| % abundance in integrins, % abundance in EF hands | |||||||||
| D | 97, 99 | 0, 0 | 41, 76 | 3, 2 | 79, 47 | 5, 1 | 0, 1 | 8, 0 | 96, 34 |
| N | 0, 0 | 0, 1 | 48, 22 | 9, 8 | 21, 24 | 1, 2 | 2, 1 | 13, 0 | 1, 4 |
| E | 3, 0 | 0, 7 | 1, 0 | 4, 2 | 0, 1 | 0, 0 | 3, 7 | 9, 0 | 3, 13 |
| Q | 0, 0 | 0, 11 | 0, 0 | 18, 5 | 0, 0 | 0, 1 | 1, 4 | 9, 0 | 0, 2 |
| ST | 0, 0 | 0, 16 | 9, 1 | 5, 3 | 0, 29 | 14, 0 | 8, 30 | 23, 0 | 0, 34 |
| G | 0, 0 | 0, 0 | 1, 0 | 34, 53 | 0, 0 | 68, 93 | 0, 0 | 1, 0 | 0, 12 |
| AVLICM | 0, 0 | 91, 26 | 0, 1 | 12, 1 | 0, 0 | 2, 1 | 30, 12 | 15, 100 | 0, 1 |
| P | 0, 0 | 0, 0 | 0, 0 | 0, 0 | 0, 0 | 0, 0 | 0, 0 | 23, 0 | 0, 0 |
| FYW | 0, 0 | 9, 2 | 0, 0 | 0, 0 | 0, 0 | 1, 0 | 54, 27 | 0, 0 | 0, 0 |
| HRK | 0, 0 | 0, 36 | 0, 0 | 15, 26 | 0, 0 | 9, 2 | 3, 19 | 1,0 | 0, 0 |
Residues in the calcium binding sites (a total of 117) from all available integrin sequences were counted. The EF hand sequences were taken from ref. 45. Only eucaryotic EF hand sequences with observed or inferred calcium binding that had no insertion or deletion (a total of 498 calcium binding sequences) were analyzed. The residues are given by one-letter code.