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Reactions catalyzed by TRs. TRs reduce the carbonyl group of a common substrate, tropinone, to hydroxy groups with different configurations. The reaction products tropine (3α-hydroxytropane) and ψ-tropine (3β-hydroxytropane) do not interconvert, rather they are further metabolized to various alkaloid products. Both enzymes require NADPH as the hydride donor. Carbon atoms of the tropane ring system are numbered in tropinone.
