Table 2.

Antitumor effect of EBV-CTL adoptive transfer

Mice	EBV-CTLs	EBV-CTLs	EBV-CTLs	EBV-CTLs
	ΔCD34v	+ rhIL-2	iC.ΔCD34/IL-2v	iC.ΔCD34/IL-15v
Inoculated with EBV-LCLs	17	24	19	17
Tumor free 4 to 6 weeks after CTL transfer	0	4 (17%)	9 (47%)*	9 (53%)†

ΔCD34v indicates CTLs transduced with the ΔCD34 control vector; iC.ΔCD34/IL-2v, CTLs transduced with the vector encoding for IL-2; iC.ΔCD34/IL-15v, CTLs transduced with the vector encoding for IL-15v. Mice injected with these CTLs did not receive exogenous cytokines. EBV-CTLs indicates CTLs non transduced. Mice infused with control EBV-CTLs received exogenous rhIL-2 (1000 U/mL) intraperitoneally every 2 days.

^*P = .001.

^†P < .001 when compared to control EBV-CTLs ΔCD34v by Fisher exact test.