Table 7.
Genes up- and down-regulated in patients with poor response to treatment
| Gene symbol | Gene name | Fold change | P | FDR |
|---|---|---|---|---|
| In patients with poor response to treatment | ||||
| IL21R | Interleukin-21 receptor | 2.81 | < .001 | .048 |
| MYO7A | Myosin VIIA (usher syndrome 1B [autosomal recessive, severe]) | 2.44 | < .001 | .048 |
| RGS16 | Regulator of G-protein signaling 16 | 2.29 | < .001 | < .001 |
| ANP32E | Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 2.00 | < .001 | < .001 |
| SLA | Src-like adaptor | 1.91 | < .001 | .048 |
| PPP1R16B | Protein phosphatase 1, regulatory (inhibitor) subunit 16B | 1.79 | < .001 | .048 |
| C1GALT1 | Core 1 synthase | 1.64 | < .001 | .048 |
| IL10 | Interleukin-10 | 1.60 | < .001 | < .001 |
| TRIB2 | Tribbles homolog 2 (Drosophila) | 1.55 | < .001 | < .001 |
| MTHFD2 | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 1.51 | < .001 | < .001 |
| EHD1 | EH-domain containing 1 | 1.51 | < .001 | < .001 |
| In patients with good response to treatment | ||||
| WIF1 | WNT inhibitory factor 1 | 4.02 | < .001 | .048 |
| KRT15 | Keratin 15 | 1.92 | < .001 | < .001 |
| GSTA3 | Glutathione S-transferase A3 | 1.87 | < .001 | .048 |
| PTN | Pleiotrophin (heparin-binding growth factor 8, neurite growth-promoting factor 1) | 1.79 | < .001 | .048 |
Shown are genes with fold change greater than or equal to 1.5, P value less than or equal to .05, and FDR less than or equal to 0.05.