Figure 1.

The NIMA-related kinase family. A. A phylogenetic tree generated by a manually edited multiple sequence alignment of the catalytic domains of the eleven human NIMA-related kinases using the Neighbor Joining method in ClustalX. B. A schematic representation of the two fungal (Aspergillus NIMA and S. pombe Fin1) and four mammalian (Nek2, Nek6, Nek7 and Nek9) NIMA-related kinases implicated in mitotic regulation indicating the relative positions of different domains and motifs. Three splice variants of Nek2 have been described; the longest of these, Nek2A, is shown here. Numbers represent protein length in amino acids.