Table 2.
Analysis of TiO2-nanoparticle distribution 24 h after exposure.
Compartment | NO | P | NE | RDI | Χ2 | Fraction of total Χ2 |
Air | 348 | 2052 | 363 | 0.96 | 0.59 | 0.039 |
Epi/Endo | 17 | 131 | 23 | 0.73 | 1.63 | 0.109 |
CT | 11 | 54 | 10 | 1.15 | 0.22 | 0.015 |
Caplum | 49 | 168 | 30 | 1.65 | 12.56 | 0.837 |
Total | 425 | 2405 | 425 | 15.01 |
Note. The calculation of the data is described in the Methods section and an illustrating example is provided in the note to table 1. With three degrees of freedom (2-1 groups × 4-1 compartments) and a total chi-squared value of 15.01, the null-hypothesis of random distribution has to be rejected (p < 0.01). The capillary lumen has an RDI of 1.65 and a partial chi-squared value that contributes about 84% of the total chi-squared. It is the only compartment that meets both criteria for a preferential deposition. Abbreviations: Air: Air space; Epi/Endo: Epithelial/endothelial cells; CT: Connective tissue; Caplum: Capillary lumen. Χ2: Chi-squared test values. NO: Observed number of particles. NE: Expected number of particles. RDI: Relative deposition index.