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IC50 values for the inhibition of cytokine protein synthesis by CsA in ABL and CBL
| Cytokine | CBL (nM) | ABL (nM) |
| IL-2 | 4.52 ± 0.70 | 3.36 ± 0.13 |
| IFNγ | 4.32 ± 0.89 | 12.60 ± 5.05 |
| IL-4 | 3.43 ± 0.68 | 3.71 ± 0.16 |
| IL-5 | 3.27 ± 0.91 | 4.73 ± 1.23 |
| IL-13 | 4.42 ± 0.67 | 3.74 ± 0.06 |
| IL-3 | 3.20 ± 0.41 | 5.56 ± 1.03 |
| GM-CSF | 7.75 ± 0.53 | 9.02 ± 0.44 |
Cells were stimulated by TPA/ionomycin for 24 hrs. Protein levels were determined in the supernatant by ELISA. Data shown are mean IC50 ± standard error for 3 donors.
