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Schematic representation and sequence comparison of EC1 and TM1 domains of xCRF-R1 and hCRF-R1. The conserved amino acids within EC1 and TM1 are presented as dashes in the hCRF-R1 sequence. The residues that have been mutated are highlighted, and the junctions of chimeric receptors (residues 67/68, 92/93, and 123/124) are indicated by X.
