Labeled BR viewed from within the plane of the membrane: Red, retinal molecule; yellow, Trp (W86, W182, W138, and W189) and Met (M20, M118, and M45) residues in the retinal pocket; blue, Trp (W10, W12, W80, and W137) and Met (M32, M56, M60, M68, M163, and M209) residues out of the retinal pocket [Protein Data Bank atomic coordinates from Grigorieff et al. (4)].