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. Author manuscript; available in PMC: 2008 Jan 1.
Published in final edited form as: Neurosci Biobehav Rev. 2007 Mar 15;31(6):920–931. doi: 10.1016/j.neubiorev.2007.03.002

Figure 2. PI3K-Akt-GSK-3 Signaling Pathways.

Figure 2.

BDNF binds to the TrkB receptor. This leads to the phosphorylation of Shc. Phosphorylated Shc recruits the Grb2-SOS complex. This in turn activates separately Ras and Gab1 followed by Gab2. Both paths lead to activation of PI3K. Activated PI3K produces 3-phosphoinositides that recruit PDK which in turn activates Akt-1 through phosphorylation. Akt-1 then inhibits GSK-3β by phosphorylation.