Table 2. Effect of a Lithogenic Diet on Biliary Lipids.

	No. of pools	Diet	TBA mM	PPL mM	XOL mg/ml	TBA mol%	PPL mol%	XOL mol%	TL g/dl	CSI
Lean	14	chow	216.1±9.8a	43.6±3.2a	3.5±0.5a	81.1±1.1a	16.2±0.9a	3.4±0.4a	14.1±0.6a	0.6±0.1a
Het-Ob	13	chow	185.3±7.0b	32.6±1.7b	2.1±0.2b	83.0±0.5a	14.6±0.5ab	2.4±0.1a	11.8±0.5b	0.4±0.02a
Homo-Ob	11	chow	272.8±18.1c	50.6±4.5a	3.6±0.6a	83.9±1.3a	12.9±0.7b	3.2±0.6a	16.9±1.0c	0.6±0.1a
Lean	10	xol	210.5±10.7d	38.4±1.5d	6.3±0.5*c	78.6±1.5bc	14.7±0.9c	7.0±0.7*b	13.9±0.4d	1.2±0.1*b
Het-Ob	10	xol	230.7±4.1*d	37.1±1.9d	6.7±0.5*c	80.8±0.7c	13.0±0.5c	6.1±0.4*b	14.8±0.4*d	1.1±0.05*b
Homo-Ob	8	xol	171.5±10.7*e	40.5±2.4d	4.8±0.4d	74.0±1.4*b	17.3±1.5*d	5.8±0.3*b	12.5±0.6*d	0.9±0.1*b
Two-Way ANOVA p-value
Strain Effects			0.447	<0.001	0.367	0.126	0.396	0.53	0.033	0.61
Diet Effects			0.024	0.003	0.001	<0.001	0.052	<0.001	0.056	<0.001
Strain-Diet Interaction			<0.001	<0.001	0.002	0.016	<0.001	0.326	<0.001	0.252

NOTE: Data represent mean ±SEM.

Different superscript letters among strains on same diet indicate significant difference from one another, p < 0.001.*p < 0.05 vs same strain on chow diet.

Abbreviations: TBA = Total Bile Acids, PPL = Phospholipids, XOL = Cholesterol, TL = Total lipids, CSI = Cholesterol Saturation Index.