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Nicotine-stimulated [3H]DA release from dorsal striatum of male and female animals. EC50s (95% confidence intervals) and maximum release (mean ± SEM) are from 3-6 independent experiments.
| Age | EC50 (μM) | Max. Release (%) | ||
|---|---|---|---|---|
| Male | Female | Male | Female | |
| 30 | 3.26 (2.3-4.6) |
2.14 (0.7-6.7) |
7.7 ± 0.26 | 4.87 ± 1.01 |
| 40 | 1.42 (0.3-6.4) |
3.9 (1.5-9.9) |
6.60 ± 1.00 | 7.39 ± 1.32 |
| Ad | 2.55 (0.9-7.1) |
2.05 (0.7-6.1) |
6.39 ± 0.62 | 7.33 ± 0.85 |
