Figure 5.
Multiple polarization changes during injection of decreasing FMLP concentrations from 10−8 to 10−10 M at 10-s intervals. Two representative cells from independent experiments are shown in A–F and G–L. The cells flip their morphological polarization five times (each flip corresponds to one “tooth” in the sawtooth injection profile). The directions of cell polarizations (the thick or lamellipodial end of the cell) is noted by the direction of arrows. Note that surrounding materials remain in constant positions, but the cell orientation changes. (Magnification, ×1,266)