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RAW and RES cells were incubated in serum-free RPMI 1640 medium for 18 h before treatment with 200 μM GSNO for the times indicated. MAPK activity is indicated by phosphorylation of Elk-1. The level of MAPK increases in both RAW and RES cells, although the basal level in RAW cells is higher than that of the RES cells. Although the basal levels differ, the maximal response in MAPK activity appears to peak between 10 and 15 min and then decline thereafter.
