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Thymic lymphoma formed after exposure to a low dose of MNU
| Genotype | Sex | Number of treated mice | Number of mice with thymic lymphoma |
|---|---|---|---|
| MGMT+/+ MLH1+/+ | F | 19 | 0 (0%) |
| M | 17 | 0 (0%) | |
| MGMT−/− MLH1−/− | F | 17 | 13* (76%) |
| M | 21 | 14 (67%) | |
| MGMT+/+ MLH1−/− | F | 22 | 9 (41%) |
| M | 15 | 1 (7%) |
Mice (6 weeks old) were given 30 mg/kg of body weight of MNU i.p. and killed 8 weeks later.
Three mice died with thymic lymphoma 31, 46, and 51 days after MNU treatment.
