Figure 4.

Food intake, lipid oxidation, and locomotor activity in male LP and HP mice. Abbreviations: FoxS1, forkhead transcription factor; Phex, phosphate-regulating gene with homologies to endopeptidases on the X chromosome. (A) Food intake measured at 3 and 6 months of age (n = 12/group). Metabolic rate (V0₂; B) and RER in the resting period (C) determined by indirect calorimetry analysis. Locomotor activity was higher in the first part of the dark phase in adult HP mice compared with LP mice (n = 11–12/group) as represented by an actiogram (D) or as the average daily activity over a 24-hr period (E). Gene expression determined by real-time quantitative PCR in hypothalami (F) is shown for each gene as percent of expression in HP mice relative to LP animals (n = 10/group). Results are mean ± SE.

*p < 0.05, **p < 0.01, and ^#p < 0.001 versus control.