Figure 1.

Total sleep deprivation from 0–5 h after training selectively impairs memory for contextual conditioning. (A) Mice sleep deprived from 0–5 h after training freeze less in response to the shocked context than do nonsleep-deprived mice (context; P < .05; n = 21 per group). Sleep-deprived mice did not differ from nonsleep-deprived mice in freezing in the altered chamber (preconditioned stimulus [pre CS]) or in freezing in response to the noise cue (conditioned stimulus [CS]; P > .05; n = 15 per group). (B) Mice show a deficit in the specificity of freezing to the shocked context when sleep deprived from 0–5 h after training for fear conditioning. Specificity of freezing to the shocked context (delta context) measured by the difference in percent freezing between the shocked and altered context was significantly less in mice that were sleep deprived from 0–5 h after training than in nonsleep-deprived mice (P < 0.01; n = 15 per group). Cue-specific freezing (delta cue) is not altered by sleep deprivation from 0–5 h after training (P > .05; n = 15 per group). *, P < .05.