Table 3.
GAD and Synaptophysin Data for Each Group
| Sex | Assay | Brain region | Adult social control | Middle-aged social control | Middle-aged enriched |
|---|---|---|---|---|---|
| Male | GADa | Neocortex | 168.1 ± 6.9 | 173.7 ± 6.6 | 176.9 ± 11.3 |
| Hippocampus | 180.5 ± 9.4 | 168.5 ± 7.8 | 214.0 ± 12.5c | ||
| Synaptophysinb | Neocortex | 0.93 ± 0.02 | 0.96 ± 0.03 | 0.94 ± 0.05 | |
| Hippocampus | 1.32 ± 0.07 | 1.28 ± 0.07 | 1.13 ± 0.07 | ||
| Female | GAD | Neocortex | 186.3 ± 10.3 | 170.8 ± 7.6 | 159.5 ± 8.3 |
| Hippocampus | 211.4 ± 20.2 | 166.1 ± 11.6 | 164.2 ± 19.2 | ||
| Synaptophysin | Neocortex | 1.03 ± 0.03 | 1.03 ± 0.04 | 0.94 ± 0.05 | |
| Hippocampus | 1.35 ± 0.06 | 1.39 ± 0.06 | 1.20 ± 0.06 |
a
Values represent the mean nmol product/hr/mg protein ± SEM.
b
Values represent mean ± SEM MBS synaptophysin equivalents expressed as sample immunoreactivity relative to that of an equal amount of mouse brain standard.
c
P < 0.05 relative to adult and middle-aged social controls.