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. 2003 Jul;10(4):247–252. doi: 10.1101/lm.59103

Figure 2.

Figure 2

TA–CA1 LTP is sensitive to a GABAB receptor antagonist. (A) Ensemble average of all TA–CA1 experiments conducted in the presence of the GABAA receptor antagonist bicuculline; LTP was not affected by bicuculline. The scale bar for all panels, 0.5 mV, 20 msec. (B) Ensemble average of all TA–CA1 experiments conducted in the presence of the GABAB receptor antagonist, CGP; LTP was significantly inhibited by CGP. (C) Ensemble average of all TA–CA1 experiments conducted in the presence of both a GABAA and a GABAB receptor antagonist. As predicted, CGP no longer inhibited LTP; the combination of inhibitors increased the magnitude of LTP. (D) Summary graph showing the magnitude of potentiation observed in TBS and HFS early-LTP experiments. Asterisks indicate groups that differed significantly from the TA–LTP group in ACSF as determined by an ANOVA.