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DNA sequencing of identical TCR-β clonotypes. 100% sequence identity of the TCR-β-variable gene region of FLU- or GAG-stimulated lymphocytes was obtained using a BV17 primer. This sequence includes the CDR3 hypervariable D/J region between the 'CASS' coding sequence and the BC region (both in gray), which greatly influences the HLA/peptide binding specificity of the TCR molecule.
