β-Gal activity of cells expressing Wbp1-Cub-PLV
together with Nub-fusion proteins. (A) YG0673 cells
expressing Wbp1-Cub-PLV and (i)
NubI-Alg5, NubA-Alg5, or
NubG-Alg5 from a CEN/ARS plasmid; (ii)
NubI-Alg5, NubA-Alg5, or
NubG-Alg5 from a 2-μm plasmid; (iii)
Ost1-NubI, Ost1-NubA, or
Ost1-NubG from an integrated fusion gene (no wild-type
Ost1p present in the cell); (iv)
Ost1-NubI, Ost1-NubA, or
Ost1-NubG from a 2-μm plasmid in presence of the
wild-type Ost1p. As negative control, YG0673 was transformed with the
vector pRS314. Cells were grown on Whatman filters, permeabilized, and
incubated in the presence of X-Gal. Expression of β-gal resulted in
blue cells. (B) Quantitative β-gal assay of YG0673 cells
expressing Wbp1-Cub-PLV together with the vector, low copy number
pRS314(NubG-ALG5) (ARS), NubG-ALG5 (2
μm), OST1-NubG (integrated fusion gene, no wild-type
OST1 present), and OST1-NubG (2 μm, wild-type OST1
present). Shown are the results of one out of three independent
experiments.