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. Author manuscript; available in PMC: 2007 Oct 15.
Published in final edited form as: J Struct Biol. 2006 Dec 24;158(3):494–502. doi: 10.1016/j.jsb.2006.12.004

Figure 5.

Figure 5

A multiple sequence alignment of ten representative members of the RND family of transporters including AcrB from E. coli, Salmonella typhimurium and Yersinia pestis, MexB and MexD from Pseudomonas aeruginosa, SmeE from Stenotrophomonas maltophila, ArpB from Pseudomonas putida, MtrD from Nisseria gonorrhoeae and Bordotella pertussi, and TbtB from Pseudomonas stutzeri reveal the conservation of the N-terminal residues and presence of F4 and F5 (blue rectangle) as identical amino acids over all the family members indicating that these residues may play a role in biological function. Other residues implicated in ligand binding in AcrB are F386 and F388 (green circles); and F458 and F459 (purple circles). The figure was made using CLUSTALW (Thompson, Higgins et al. 1994) and ESPRIPT (Gouet, Courcelle et al. 1999).