Table 1.

Production of CD8-SF and β-chemokines from CD8⁺-enriched T cells in five groups of macaques and the association with protection from SIV infection

Group	CD8-SF, %		Chemokine, pg/ml				Immunity
	1:2	1:5	RANTES	MIP-1α	MIP-1β	IL-8
A
IXV SIV-ISCOM	95	55	1,080	2,560	680	928	Protected
1YB SIV-ISCOM	92	17	1,976	3,576	1,472	3,296	Protected
4053 SIV-ISCOM	40	ND	640	1,864	320	5,112	Protected
1XD SIV-MDP	59	18	3,808	4,456	3,024	3,336	Protected
3B SIV-MDP	94	ND	648	2,168	328	1,864	Protected
4083 SIV-MDP	64	48	2,496	2,520	1,936	4,368	Protected
4094 SIV-MDP	96	ND	1,768	2,128	1,424	2,896	Protected
Mean ± SEM	77.1 ± 8.5	34.5 ± 9.9	1,774 ± 429	2,753 ± 351	1,312 ± 360	3,400 ± 399
	t = 6.127*		t = 2.916	t = 3.655	t = 2.706	NS
	P < 0.001		P < 0.02*	P < 0.01*	P < 0.02*
B
8791 MV-ISCOM	18	ND	720	248	240	4,416	Infected
8789 MV-ISCOM	26	ND	640	288	240	5,016	Infected
4060 MV-MDP	13	ND	560	392	264	4,312	Infected
1IH MV-MDP	24	ND	560	376	256	3,232	Infected
Means ± SEM	20.3 ± 2.9		620 ± 38	326 ± 35	250 ± 6	4,244 ± 371
	t = 6.298*		t = 2.678	t = 6.869	t = 2.879	NS
	P < 0.001		P = 0.037	P < 0.001	P = 0.028
C
9008 nil	19.5	0	416	792	416	2,528	Infected
9012 nil	26.3	0	400	1,968	360	5,288	Infected
9027 nil	32.5	0	280	2,528	400	2,192	Infected
Mean ± SEM	26.1 ± 3.7	0	365 ± 42	1,762 ± 511	392 ± 16	3,326 ± 980
	t = 5.473*		t = 3.265	t = 1.595	t = 2.497	NS
	P < 0.001		P = 0.017	P = 0.186	P = 0.047
D
25 gp120/p27/Alum	42.7	2.9	192	272	408	4,608	Not challenged
87 gp120/p27/Alum	48.5	16.3	1056	536	792	10,184	Not challenged
205 gp120/p27/Alum	42.9	0	512	464	600	3,624	Not challenged
Mean ± SEM	44.7 ± 1.9	6.4 ± 5	587 ± 252	424 ± 79	660 ± 110	6,138 ± 2,042
	t = 3.706†		t = 2.385	t = 6.464	t = 1.849	NS
	P < 0.01		P = 0.044	P < 0.001	P = 0.107
E
928 C8166 cells	77.1	62.1	780	1,348	684	4,348	Not challenged

ND, not done; NS, not significant. 

^*CD8-SF from seven protected were compared with seven infected macaques (groups B and C). 

^†CD8-SF compared with those from group A.