Abstract
The parametric statistical models discussed include all those which have previously been described in the literature (Boag, 1948-lognormal; Berkson and Gage, 1952-negative exponential; Haybittle, 1959-extrapolated actuarial) and the basic data used to test the models comprised some 3000 case histories of patients treated between 1945 and 1962. The histories were followed up during the period treated between 1945 and 1962. The histories were followed up during the period 1969-71 and thus provided adequate information to validate long-term survival fractions predicted using short-term follow-up data. The results with the log-normal model showed that for series of staged carcinoma cervix patients treated during a 5-year period, satisfactory estimates of long-term survival fractions could be predicted after a minimum waiting period of 3 years for stages I and II, and 2 years for stage III. The model should be used with a value assumed for the lognormal paramater S in the range S = 0.35 to S = 0.40. Although alternative models often gave adequate predictions, the lognormal proved to be the most consistent model. This model may therefore now be used with more confidence for prospective studies on carcinoma cervix series and can provide good estimates of long-term survival fractions several years earlier than would otherwise be possible.
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Selected References
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- CUTLER S. J., EDERER F. Maximum utilization of the life table method in analyzing survival. J Chronic Dis. 1958 Dec;8(6):699–712. doi: 10.1016/0021-9681(58)90126-7. [DOI] [PubMed] [Google Scholar]
- HAYBITTLE J. L. The early estimation of the results of treatment for cancer. Br J Radiol. 1960 Aug;33:502–507. doi: 10.1259/0007-1285-33-392-502. [DOI] [PubMed] [Google Scholar]
- HAYBITTLE J. L. The estimation of the proportion of patients cured after treatment for cancer of the breast. Br J Radiol. 1959 Nov;32:725–733. doi: 10.1259/0007-1285-32-383-725. [DOI] [PubMed] [Google Scholar]
- Ronnike F. Carcinoma of the vulva. Cure after operative therapy evaluated in accordance with Boag's statistical method. Dan Med Bull. 1968 Dec;15(10):296–301. [PubMed] [Google Scholar]