Figure 5.

Desferri-exochelins (D-EXO) inhibit ⋅OH generation in hearts exposed to ischemia and reperfusion. Myocardial 2,3- and 2,5-DHBA were measured in the isolated hearts described in Fig. 4. Desferri-exochelins reduced 2,3-DHBA in a dose-dependent manner (P < 0.01 by linear regression). The dose-related change in 2,5-DHBA was at the margin of significance (P = 0.08). Because of its specificity for hydroxylation in tissue (21) and its greater retention in myocardium, the myocardial 2,3-DHBA is a more accurate index of ⋅OH production.