Figure 5.
Tumor incidence of papillomas in mice treated with DMBA and TPA. Susceptibility of the mice to the tumorigenic effects of DMBA was determined by using the initiation-promotion protocol outlined in Material and Methods. After treatment, GstP1/P2(−/−) and GstP1/P2(+/+) mice were scored for papilloma numbers on a weekly basis, and statistical analysis was carried out by using the Statview software package (Abacus Concepts, Berkeley, CA). a = P < 0.0001, b = P < 0.001.