Ramachandran plots for the (top row: a, c, e, and g) Aβ16–20 peptides and (bottom row: b, d, f, and h) Aβ16–20m peptides. a and b correspond to Lys16, c and d to Leu17, e and f to Val18, and g and h to Phe19. The conformational effect induced by the N-methylation results in the restriction of the dihedral space of residues (b) Lys16 and (f) Val18.