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Structural changes associated with pore formation. The main conformational changes are located at α1 helix, whose length and orientation change to form the pore. α2 helix and β-sandwich are supposed not to change their conformation upon lipid binding. Residues cited in the text are highlighted. The plane of the membrane surface is indicated. The diagram was constructed with VMD (61) and PyMol (DeLano Scientific, San Francisco, CA).
