Table 2.

Clinical and histopathologic features of the HNSCC specimens

UPCI:	Origina	Site	Gradeb	Path Stage	11q13c	TP53 (codon)d	HPV +e
SCC002	R	TONG	1	T4N0	○	WT	○
SCC003	NP	TONS	1	T1N0	•	-	○
SCC013	NP	MAND	2	T4N0	○	WT	○
SCC016	NP	TONG	1	T1N0	•	WT	○
SCC026	R	ALV RIDGE	1	T1NX	•	WT	○
SCC029	N	BUCCAL	3	T4N2	•	WT	○
SCC030f	NP	FOM	3	T4N2B	○	WT	○
SCC032	NP	RMT	2	T2N2B	•	WT	○
SCC036f	NP	TONS	2	T3N1	•	WT	•
SCC040	NP	TONG	2	T2N2	•	WT	○
SCC044	NP	BOT	2	T2N2C	•	WT	○
SCC045	Prior SCC	RMT	2	T2N0	○	WT	○
SCC051f	NP	RMT	-	T3N2B	•	WT	○
SCC052	NP	FOM	2	T4N2C	○	WT	○
SCC053	NP	FOM	2	T1N0	○	mut (7)	○
SCC056	NP	TONG	2	T3N2B	•	-	○
SCC062	NP	TONG	1	T3N0	•	WT	○
SCC065	NP	TONG	1	T2N0	○	WT	○
SCC066	NP	ALV	1	T1N0	○	mut (189)	○
SCC068	NP	TONG	1	T3N1	○	WT	○
SCC070	R	RMT	2	T3N1	•	WT	•
SCC072	NP	TONS	2	T3N2B	•	mut (179)	○
SCC074	NP	ALV	3	T4N1	•	mut (221)	○
SCC075	NP	TONG	2	T3N2B	○	WT	○
SCC077	NP	FOM	2	T2N2	○	WT	○
SCC078	R	FOM	2	T2N0	•	mut (158)	○
SCC080f	R	BOT	-	T1N0	•	WT	○
SCC081	NP	ALV RIDGE	2	T4N0	•	WT	○
SCC084	R	RMT	2	T2N2B	•	WT	○
SCC089	NP	TONS	2	T4N2B	•	-	○
SCC090	R	BOT	3	T2N0	○	WT	•
SCC099	R	FOM	2	T1N0	○	WT	•
SCC103	NP	TONG	1	T1N0	•	mut (306)	○
SCC104	R	FOM	2	T4NX	○	mut (245)	○
SCC105	Prior SCC	FOM	2	T2N0	○	mut (155)	○
SCC111	NP	FOM	3	T1N1	○	WT	○
SCC114	Prior SCC (2)	FOM	2	T2NX	○	mut (248)	○
SCC116	NP	ALV RIDGE	2	T2N0	○	WT	○
SCC121	NP	RMT	3	T1N0	○	WT	○
SCC122	NP	TONG	3	T1N1	○	WT	○
SCC125	NP	ALV RIDGE	2	T4N2B	○	WT	○
SCC131	NP	FOM	1	T2N2	•	WT	○
SCC136	NP	FOM/RMT	2	T3N2	•	WT	○
SCC142	R	FOM/MAND	2	T4NX	○	WT	○
SCC143	R	FOM	3	T4N2	○	WT	○
SCC152	R	HYPO	2	-	○	WT	•
SCC153	NP	ALV RIDGE	2	T2N1	•	-	•
SCC154	NP	TONG	3	T4N2	○	WT	•
SCC172	R	MAND	3	-	○	-	○
SCC182	NP	RMT	2	T2N1	○	-	○
SCC192	NP	FOM	1	T4N0	•	-	○
SCC200	NP	BOT/TONS	1	T2N2B	○	-	•

^aNP = new primary, R = recurrence, Prior SCC indicates this was not the initial primary (for SCC114 there were 2 previous primaries).

^b1 = low (well differentiated), 2 = moderate (moderately differentiated), 3 = high (poorly differentiated)

^cFilled circle indicates 11q13 amplification in the tumor.

^dIf TP53 is mutant, the codon which contains the mutation is specified.

^eFilled circle indicates HPV-positivity in the tumor.

^fUPCI:SCC030 and 036 are spindle cell SCCs, UPCI:SCC051 is an adenoid SCC, UPCI:SCC080 is a basaloid SCC.